Holmes' first experience with crack cocaine was when she smoked with her mother at the age of 12. She dropped out of school in the 10th grade. After leaving school, she moved to New York City to live with her boyfriend Ilya Leontyev. The two fell into heavy drug and alcohol abuse, with Holmes first trying heroin at the age of 17. She was largely homeless for the next three years. Leontyev died of an overdose in Central Park in April 2015.
《天知道》根据女主Arielle Holmes的真实经历改编，讲述吸毒成瘾的她流落纽约街头的故事。关于吸毒人群的电影有很多，本片在情节上并没有太大新意，但是它的呈现方式却极具张力，影像粗砺，配乐迷幻，写实的同时又自成风格。
Arielle Holmes饰演的Harley性格火爆，嗓音粗哑，一双失神的三白眼让人一看就怀疑是吸毒者。这样一个现实中见了会绕道走的角色，在片中却神奇地吸引观众进入她的世界，跟随她四处漂泊，喝酒、吸毒、乞讨、偷窃，还有跟反复无常的男友Ilya相爱相杀。影片没有交代任何背景
“天知道”轻松打破观众对瘾君子的刻板单调印象
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